Estrogen and Progesterone hormone receptor expression in oral cavity cancer
Med. oral patol. oral cir. bucal (Internet)
; 21(5): e554-e558, sept. 2016. tab, ilus
Article
in En
| IBECS
| ID: ibc-155765
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Recent studies have shown an increase in the incidence of oral squamous cell carcinoma (OSCC) in younger patients. The hypothesis that tumors could be hormonally induced during pregnancy or in young female patients without the well-known risk factors alcohol or tobacco abuse seems to be plausible. MATERIAL ANDMETHODS:
Estrogen Receptor alpha (ERá) and Progesterone Receptor (PR) expression were analyzed in normal oral mucosa (n =5), oral precursor lesions (simple hyperplasia, n = 11; squamous intraepithelial neoplasia, SIN I-III, n = 35), and OSCC specimen. OSCCs were stratified in a young female (n = 7) study cohort and older patients (n = 46). In the young female study cohort three patients (n = 3/7) developed OSCC during or shortly after pregnancy. Breast cancer tissues were used as positive control for ERá and PR expression.RESULTS:
ERá expression was found in four oral precursor lesions (squamous intraepithelial neoplasia, SIN I-III, n = 4/35, 11%) and in five OSCC specimen (n = 5/46, 11%). The five ERá positive OSCC samples were older male patients. All patients within the young female study cohort were negatively stained for both ERá and PR.CONCLUSIONS:
ER expression could be regarded as a seldom risk factor for OSCC. PR expression seems to be not relevant for the development of OSCC
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Mouth Neoplasms
/
Receptors, Progesterone
/
Receptors, Estrogen
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2016
Document type:
Article